Henrikh Mkhitaryan will be assessed ahead of the match. The midfielder took part in a warm-up with the rest of the team in training on Wednesday, but has been struggling with a mild back strain.
The Gunners will have to make do without defender Sokratis Papastathopoulos, after he saw red in the first-leg defeat.
But Alexandre Lacazette is available to play, after having his ban reduced to two games, following his red card against BATE Borisov.
Arsenal squad vs Rennes:
Cech, Leno, Maitland-Niles, Koscielny, Mustafi, Monreal, Kolasinac, Guendouzi, Torreira, Xhaka, Ramsey, Iwobi, Suarez, Mkhitaryan, Ozil, Aubameyang, Nketiah, Lacazette.