Pep Guardiola and his team travelled down to London on Friday afternoon, ahead of the crunch match at Stamford Bridge.
City go into the match 10 points ahead of Chelsea in the league.
Guardiola is spoilt for choice in the wide areas with Raheem Sterling, Riyad Mahrez and Leroy Sane all fit and available.
The champions have already secured victory over Chelsea once this season, in the Community Shield back in August.
Confirmed Manchester City squad members vs Chelsea
Goalkeepers: Ederson, Muric, Grimshaw.
Defenders: Laporte, Delph, Danilo, Otamendi, Stones, Kompany, Walker.
Midfielders: Gundogan, Silva, Foden, Fernandinho.
Forwards: Sterling, Sane, Mahrez, Jesus.